Cure PD vit

Neuroprotective potential of vitamin B6 in iPSC & in vivo neuronal models of Parkinson’s disease.

01.08.2026 bis 31.10.2028

Pyridoxal-5′-phosphate (PLP), the active form of vitamin B6, is an essential cofactor for more than 70 enzymatic reactions, including amino acid metabolism, neurotransmitter biosynthesis and iron-sulfur (Fe-S) cluster biogenesis. Nearly one-third of PLP-dependent enzymes localize to mitochondria, underscoring a critical role for vitamin B6 in mitochondrial metabolism, redox homeostasis and cellular energy production. Defects in mitochondrial quality control and metabolism are central pathogenic mechanisms in Parkinson’s disease (PD), however, how vitamin B6 homeostasis intersects with these pathways remains largely unexplored.