BROOC

Brain organoid-on-chip: a microfluidic platform to study neocortical development

01.09.2022 bis 31.08.2024

A sophisticated human model of neocortex development is required for the study of autism spectrum disorders and intellectual disability. So far, neural 2D cultures have been used but they haven’t the tissue complexity required. The EU-funded BROOC project has proposed development of controlled 3D spatio-temporal using Organ-on-chip (OoC) technology. The result, a new cerebral organoid model with multi-layered cortex structures on a microfluidic chip system within an array of integrated electrodes. This OoC platform will enable study of application of pharmaceuticals and neurodevelopmental disorders. Moreover, the technology will provide an alternative to the use of animals and provide a tool to study the molecular mechanisms of brain evolution.